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The best indicator for Biotech (XBI)

We backtested 382 indicators across daily, weekly and hourly charts on real Biotech (XBI) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.

Signaling LONG right now — Lorentzian Classification (Weekly) has been long for 1 bars. Signal computed on 2026-09-07, 2 days behind the price data on this page (it is rebuilt on a separate schedule).
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Key levels · as of 2026-09-09

Where Biotech (XBI) stands

159.38
last daily close (2026-09-09)
135.70
200-day simple moving average price 17.5% above
158.23
50-day simple moving average price 0.7% above
93.00–169.55
52-week range

Computed from our own daily OHLCV history, not quoted from a third party. Moving averages use closing prices; "52-week" is the last 252 trading sessions.

ML · Weekly

Lorentzian Classification

On the weekly chart, this is the strongest risk-adjusted edge we found for Biotech (XBI) over ~20.4 years — beating buy-and-hold by 0.4% CAGR.

11.3%
CAGR
0.57
Sharpe
-44.1%
Max DD
59.3%
Win rate
1.49
Profit factor
+0.4%
vs Buy&Hold
Chart

Biotech (XBI) on the weekly chart

The timeframe our backtest found best for this asset. The chart is live market data; the results above are hypothetical and historical.

Chart by TradingView. Loading it contacts tradingview.com, which may set its own cookies — see our privacy policy.

NOTHING BEAT BUY-AND-HOLD
Full strategy report — every setup ranked out-of-sample, corrected for data-mining, and forward-tracked in public.
Read the verdict
Confluence · Daily

Best multi-indicator combo

Supertrend (10,3)Donchian Breakout

Going long only when all 2 agree was the strongest confluence setup we found for Biotech (XBI) — trailing buy-and-hold by 5.4% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

5.6%
CAGR
0.41
Sharpe
48.1%
Win rate
79
Trades
-5.4%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
Lorentzian Classification
+0.4% · Sharpe 0.57
Daily
SMA 20/80 Cross
-2.0% · Sharpe 0.52
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1Lorentzian Classification Weekly11.3%0.57-44.1%59.3%1770.4%
2Chande Momentum Osc. Weekly9.0%0.53-35.5%52.8%72-1.9%
3Least Squares MA Weekly8.7%0.53-46.0%54.3%81-2.1%
4SMA 20/80 Cross Daily9.0%0.52-37.5%57.9%38-2.0%
5Supertrend Fast (10,2) Weekly8.5%0.52-30.5%52.0%25-2.3%
6Connors RSI Weekly7.7%0.52-28.9%72.9%48-3.2%
7Demand Index Weekly9.5%0.52-49.4%73.1%52-1.3%
8Supertrend (7,2) Weekly8.5%0.52-26.5%56.0%25-2.4%
9Supertrend (10,2) Weekly8.5%0.52-30.5%52.0%25-2.3%
10Negative Volume Index Daily10.3%0.51-62.2%45.5%33-0.6%
11TEMA 20/50 Cross Weekly8.2%0.51-29.3%63.2%19-2.6%
12PMax Daily8.5%0.51-42.0%67.9%28-2.5%
13CCI Daily8.5%0.5-36.0%68.0%103-2.4%
14T3 10/40 Cross Daily8.4%0.5-45.2%57.6%59-2.6%

= held up out-of-sample. Hypothetical, costs included. See methodology.

The leverage question

What it would take to beat buy & hold on Biotech (XBI)

113 of 602 tested setups beat buy-and-hold on Biotech (XBI) outright. Another 122 could get there with leverage they would survive — but 94 would be liquidated by their own drawdown before they caught it.

IndicatorBeats B&H unlevered Leverage neededLeverage survived
Williams %R (50)11.04×2.54×
DeMarker (21)11.28×2.24×
DEMA 100 Trend11.49×2.26×
ZLEMA 100 Trend11.49×3.05×
Pivot Points (Standard)11.82×2.75×
Fibonacci Pivots11.94×2.55×

Out-of-sample, costs included. A setup is only listed if the leverage it needs is less than the leverage its own worst drawdown survives — when it isn't, no amount of leverage gets there. Volatility drag isn't modelled, so these are the optimistic case. Every indicator, ranked this way

What this means

For Biotech (XBI), Lorentzian Classification on the weekly timeframe gave the best balance of return and risk in our test. It beat buy-and-hold — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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