The best indicator for Biotech (IBB)
We backtested 366 indicators across daily, weekly and hourly charts on real Biotech (IBB) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.
Bollinger Mean-Reversion
On the weekly chart, this is the strongest risk-adjusted edge we found for Biotech (IBB) over ~25.4 years — trailing buy-and-hold by 1.6% CAGR.
Best multi-indicator combo
Going long only when all 2 agree was the strongest confluence setup we found for Biotech (IBB) — trailing buy-and-hold by 3.3% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.
The winner on each chart
Every indicator, ranked
Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.
| # | Indicator | TF | CAGR | Sharpe | Max DD | Win | Trades | vs B&H |
|---|---|---|---|---|---|---|---|---|
| 1 | Bollinger Mean-Reversion ✓ | Weekly | 5.3% | 0.48 | -31.0% | 72.7% | 22 | -1.6% |
| 2 | LSMA 10/30 Cross ✓ | Weekly | 6.3% | 0.48 | -29.3% | 54.5% | 55 | -0.6% |
| 3 | Fibonacci Bands ✓ | Weekly | 5.3% | 0.48 | -31.0% | 72.7% | 22 | -1.6% |
| 4 | Least Squares MA ✓ | Weekly | 6.0% | 0.47 | -38.3% | 50.0% | 96 | -0.9% |
| 5 | Zero-Lag LSMA ✓ | Weekly | 6.3% | 0.47 | -37.1% | 51.0% | 98 | -0.6% |
| 6 | QQE ✓ | Weekly | 8.1% | 0.47 | -44.9% | 55.6% | 72 | 1.1% |
| 7 | Negative Volume Index ✓ | Daily | 7.2% | 0.44 | -39.2% | 54.8% | 42 | 0.5% |
| 8 | CCI (50) ✓ | Daily | 6.0% | 0.44 | -33.8% | 37.6% | 178 | -0.7% |
| 9 | Trend Regularity Adaptive MA ✓ | Weekly | 5.4% | 0.44 | -28.8% | 30.8% | 26 | -1.5% |
| 10 | SMC: Liquidity Sweep ✓ | Weekly | 5.6% | 0.44 | -41.5% | 84.2% | 19 | -1.3% |
| 11 | EMA 8/21 Cross ✓ | Daily | 5.9% | 0.43 | -30.3% | 39.4% | 142 | -0.8% |
| 12 | DeMarker ✓ | Weekly | 4.8% | 0.43 | -28.4% | 81.0% | 21 | -2.1% |
| 13 | Accelerator Oscillator ✓ | Weekly | 5.4% | 0.43 | -24.0% | 52.6% | 78 | -1.5% |
| 14 | Parabolic SAR ✓ | Weekly | 5.5% | 0.42 | -42.1% | 51.7% | 60 | -1.4% |
✓ = held up out-of-sample. Hypothetical, costs included. See methodology.
For Biotech (IBB), Bollinger Mean-Reversion on the weekly timeframe gave the best balance of return and risk in our test. It still trailed buy-and-hold on raw return — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.
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