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The best indicator for Lilly (Eli) (LLY)

We backtested 366 indicators across daily, weekly and hourly charts on real Lilly (Eli) (LLY) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.

Signaling LONG right now — Volume Flow Indicator (Weekly) has been long for 429 bars, as of 2026-06-08.
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Volume · Weekly

Volume Flow Indicator

On the weekly chart, this is the strongest risk-adjusted edge we found for Lilly (Eli) (LLY) over ~54.2 years — beating buy-and-hold by 0.9% CAGR.

14.9%
CAGR
0.73
Sharpe
-54.0%
Max DD
50.0%
Win rate
74.69
Profit factor
+0.9%
vs Buy&Hold
Confluence · Weekly

Best multi-indicator combo

EMA 20/50 CrossDonchian Breakout

Going long only when all 2 agree was the strongest confluence setup we found for Lilly (Eli) (LLY) — trailing buy-and-hold by 7.5% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

6.6%
CAGR
0.44
Sharpe
48.9%
Win rate
45
Trades
-7.5%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
Volume Flow Indicator
+0.9% · Sharpe 0.73
Daily
Ultimate Oscillator
-4.6% · Sharpe 0.62
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1Volume Flow Indicator Weekly14.9%0.73-54.0%50.0%140.9%
2TRIMA 200 Trend Weekly12.9%0.65-42.0%46.7%15-1.2%
3SMA 200 Trend Weekly12.5%0.63-55.1%29.2%24-1.6%
4CCI (200) Weekly12.6%0.63-64.3%45.5%22-1.5%
5Markov Regime Weekly13.2%0.63-63.5%44.2%43-0.9%
6Ultimate Oscillator Daily9.5%0.62-47.1%83.6%55-4.6%
7Positive Volume Index Daily10.9%0.61-48.4%34.9%109-3.2%
8McGinley 200 Trend Daily13.4%0.61-68.3%30.8%39-0.7%
9EMA 200 Trend Weekly12.1%0.61-65.2%37.9%29-1.9%
10Vegas Tunnel Weekly11.2%0.59-53.4%53.1%32-2.9%
11Markov Regime Daily12.5%0.59-68.3%69.9%249-1.6%
12T3 20/80 Cross Weekly12.5%0.68-39.8%61.5%13-1.5%
13Positive Volume Index Weekly10.6%0.58-56.3%50.0%24-3.5%
14McGinley 30 Trend Weekly12.6%0.58-67.3%36.7%30-1.5%

= held up out-of-sample. Hypothetical, costs included. See methodology.

What this means

For Lilly (Eli) (LLY), Volume Flow Indicator on the weekly timeframe gave the best balance of return and risk in our test. It beat buy-and-hold — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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