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The best indicator for McKesson Corporation (MCK)

We backtested 382 indicators across daily, weekly and hourly charts on real McKesson Corporation (MCK) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.

Signaling FLAT right now — Detrended Price Osc. (Weekly) is out of the market. Signal computed on 2026-09-07, 3 days behind the price data on this page (it is rebuilt on a separate schedule).
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Key levels · as of 2026-09-10

Where McKesson Corporation (MCK) stands

880.86
last daily close (2026-09-10)
842.00
200-day simple moving average price 4.6% above
854.37
50-day simple moving average price 3.1% above
687.42–993.53
52-week range

Computed from our own daily OHLCV history, not quoted from a third party. Moving averages use closing prices; "52-week" is the last 252 trading sessions.

Oscillator · Weekly

Detrended Price Osc.

On the weekly chart, this is the strongest risk-adjusted edge we found for McKesson Corporation (MCK) over ~31.7 years — beating buy-and-hold by 0.5% CAGR.

14.4%
CAGR
0.74
Sharpe
-41.0%
Max DD
57.8%
Win rate
1.59
Profit factor
+0.5%
vs Buy&Hold
Chart

McKesson Corporation (MCK) on the weekly chart

The timeframe our backtest found best for this asset. The chart is live market data; the results above are hypothetical and historical.

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MIXED
Full strategy report — every setup ranked out-of-sample, corrected for data-mining, and forward-tracked in public.
Read the verdict
Confluence · Weekly

Best multi-indicator combo

EMA 20/50 CrossQQE

Going long only when all 2 agree was the strongest confluence setup we found for McKesson Corporation (MCK) — trailing buy-and-hold by 2.8% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

11.2%
CAGR
0.58
Sharpe
45.9%
Win rate
85
Trades
-2.8%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
Detrended Price Osc.
+0.5% · Sharpe 0.74
Daily
Positive Volume Index
-1.6% · Sharpe 0.69
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1Detrended Price Osc. Weekly14.4%0.74-41.0%57.8%1920.5%
2ADXR Weekly12.5%0.74-30.1%61.0%41-1.4%
3DeMarker (21) Weekly13.1%0.7-35.1%51.0%51-0.8%
4Positive Volume Index Daily12.3%0.69-40.8%39.7%58-1.6%
5EMA 20/80 Cross Daily12.9%0.68-56.2%46.7%45-1.0%
6VIDYA 10/30 Cross Daily13.0%0.67-47.9%57.7%26-1.0%
7ADX / DMI Weekly11.1%0.67-39.5%59.0%39-2.8%
8DMI Direction Weekly12.0%0.66-55.8%49.1%55-1.9%
9EMA 10/40 Cross Daily12.2%0.65-58.8%49.0%102-1.7%
10CCI (200) Daily12.2%0.65-45.7%32.9%82-1.8%
11Supertrend (7,2) Weekly12.4%0.65-63.8%59.4%32-1.5%
12Supertrend Fast (10,2) Weekly12.1%0.64-63.8%59.4%32-1.8%
13CMO (21) Weekly12.4%0.64-47.6%43.1%58-1.6%
14KAMA 30 Trend Weekly12.2%0.64-55.7%52.5%59-1.7%

= held up out-of-sample. Hypothetical, costs included. See methodology.

The leverage question

What it would take to beat buy & hold on McKesson Corporation (MCK)

1 of 661 tested setups beat buy-and-hold on McKesson Corporation (MCK) outright. Another 133 could get there with leverage they would survive — but 367 would be liquidated by their own drawdown before they caught it.

IndicatorBeats B&H unlevered Leverage neededLeverage survived
Detrended Price Osc.1none needed4.29×
Zero-Lag MACD1.79×3.32×
QQE1.14×2.54×
VIDYA 30 Trend1.46×2.72×
KAMA 200 Trend1.61×3.2×
KAMA 100 Trend1.68×3.04×

Out-of-sample, costs included. A setup is only listed if the leverage it needs is less than the leverage its own worst drawdown survives — when it isn't, no amount of leverage gets there. Volatility drag isn't modelled, so these are the optimistic case. Every indicator, ranked this way

What this means

For McKesson Corporation (MCK), Detrended Price Osc. on the weekly timeframe gave the best balance of return and risk in our test. It beat buy-and-hold — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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