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The best indicator for McKesson Corporation (MCK)

We backtested 366 indicators across daily, weekly and hourly charts on real McKesson Corporation (MCK) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.

Signaling LONG right now — Detrended Price Osc. (Weekly) has been long for 8 bars, as of 2026-06-08.
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Oscillator · Weekly

Detrended Price Osc.

On the weekly chart, this is the strongest risk-adjusted edge we found for McKesson Corporation (MCK) over ~31.7 years — beating buy-and-hold by 0.5% CAGR.

14.4%
CAGR
0.74
Sharpe
-41.0%
Max DD
57.8%
Win rate
1.59
Profit factor
+0.5%
vs Buy&Hold
Confluence · Weekly

Best multi-indicator combo

EMA 20/50 CrossQQE

Going long only when all 2 agree was the strongest confluence setup we found for McKesson Corporation (MCK) — trailing buy-and-hold by 2.8% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

11.2%
CAGR
0.58
Sharpe
45.9%
Win rate
85
Trades
-2.8%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
Detrended Price Osc.
+0.5% · Sharpe 0.74
Daily
Positive Volume Index
-1.6% · Sharpe 0.69
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1Detrended Price Osc. Weekly14.4%0.74-41.0%57.8%1920.5%
2ADXR Weekly12.5%0.74-30.1%61.0%41-1.4%
3DeMarker (21) Weekly13.1%0.7-35.1%51.0%51-0.8%
4Positive Volume Index Daily12.3%0.69-40.8%39.7%58-1.6%
5EMA 20/80 Cross Daily12.9%0.68-56.2%46.7%45-1.0%
6VIDYA 10/30 Cross Daily13.0%0.67-47.9%57.7%26-1.0%
7ADX / DMI Weekly11.1%0.67-39.5%59.0%39-2.8%
8DMI Direction Weekly12.0%0.66-55.8%49.1%55-1.9%
9EMA 10/40 Cross Daily12.2%0.65-58.8%49.0%102-1.7%
10CCI (200) Daily12.2%0.65-45.7%32.9%82-1.8%
11Supertrend (7,2) Weekly12.4%0.65-63.8%59.4%32-1.5%
12Supertrend Fast (10,2) Weekly12.1%0.64-63.8%59.4%32-1.8%
13CMO (21) Weekly12.4%0.64-47.6%43.1%58-1.6%
14KAMA 30 Trend Weekly12.2%0.64-55.7%52.5%59-1.7%

= held up out-of-sample. Hypothetical, costs included. See methodology.

What this means

For McKesson Corporation (MCK), Detrended Price Osc. on the weekly timeframe gave the best balance of return and risk in our test. It beat buy-and-hold — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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