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The best indicator for Amgen (AMGN)

We backtested 366 indicators across daily, weekly and hourly charts on real Amgen (AMGN) history. Here's what actually worked — risk-adjusted, out-of-sample, with costs.

Signaling LONG right now — SMC: Change of Character (Weekly) has been long for 52 bars, as of 2026-06-08.
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Smart Money · Weekly

SMC: Change of Character

On the weekly chart, this is the strongest risk-adjusted edge we found for Amgen (AMGN) over ~43.1 years — trailing buy-and-hold by 1.6% CAGR.

16.9%
CAGR
0.68
Sharpe
-62.0%
Max DD
58.3%
Win rate
16.89
Profit factor
-1.6%
vs Buy&Hold
Confluence · Weekly

Best multi-indicator combo

StochasticQQE

Going long only when all 2 agree was the strongest confluence setup we found for Amgen (AMGN) — trailing buy-and-hold by 11.6% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

6.9%
CAGR
0.46
Sharpe
69.5%
Win rate
59
Trades
-11.6%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
SMC: Change of Character
-1.6% · Sharpe 0.68
Daily
T3 10/40 Cross
-4.7% · Sharpe 0.62
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1SMC: Change of Character Weekly16.9%0.68-62.0%58.3%24-1.6%
2Markov Regime Weekly17.4%0.68-65.8%55.0%120-1.1%
3Zero-Lag LSMA Weekly14.2%0.65-58.5%55.9%145-4.3%
4QQE Weekly17.8%0.65-56.4%49.6%133-0.7%
5HMA 9/21 Cross Weekly14.3%0.64-56.9%55.6%144-4.2%
6Trend Intensity Index Weekly15.8%0.63-61.0%73.3%15-2.7%
7T3 10/40 Cross Daily13.8%0.62-53.8%53.3%137-4.7%
8Net Volume Weekly15.1%0.62-61.5%50.0%110-3.4%
9Liquidity Flow Oscillator Weekly15.1%0.62-61.5%50.0%110-3.4%
10Intraday Momentum Index Daily12.9%0.61-59.2%77.1%118-5.7%
11VIDYA 100 Trend Daily15.7%0.61-70.1%34.8%66-2.9%
12SMA 15/60 Cross Weekly15.3%0.61-69.3%52.4%21-3.2%
13SMA 20/80 Cross Weekly15.2%0.61-57.7%61.1%18-3.3%
14SMC: Break of Structure Weekly14.8%0.61-62.9%56.5%23-3.7%

= held up out-of-sample. Hypothetical, costs included. See methodology.

What this means

For Amgen (AMGN), SMC: Change of Character on the weekly timeframe gave the best balance of return and risk in our test. It still trailed buy-and-hold on raw return — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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