Does anything beat buy & hold on Pfizer (PFE)?
Every setup we tested on Pfizer (PFE) — ranked out-of-sample, corrected for multiple testing, and forward-tracked in public from the day this page published. The honest answer is the headline.
No setup beat simply holding once tested honestly. We say so plainly.
Its best setup trailed buy-and-hold out-of-sample. Buy-and-hold benchmark: +10.1% CAGR over 54.0 years (+7.3% CAGR in the out-of-sample window).
Educational research from historical backtests — not investment advice. Past performance does not predict future results.
PFE: we tested 761 setups and none beat simply holding Pfizer
For Pfizer (PFE), we ran 761 indicator configurations against a plain buy-and-hold benchmark, and none of them earned the right to replace it. Individual stocks carry idiosyncratic risk — earnings surprises, guidance changes, sector rotation — that indicators built on price history cannot see coming. The best-looking setup, Murrey Math Lines on the daily timeframe, ranked at the top in-sample but delivered an out-of-sample Sharpe of 0.57, short of our hurdle of 0.91. Buy-and-hold returned +10.1% annualized over the test period; the top strategies mostly captured pieces of that same move while adding trading friction.
How to read this honestly: when you test 761 setups and keep the best one, something will always look impressive by chance alone. That is why we require the survivor to clear 0.91 out of sample. Murrey Math Lines managed 0.57, with out-of-sample alpha of 0.0% across 16.2 years and 151 trades, and only 0.1% of everything we tested beat the benchmark on unseen data — roughly what luck would produce. None of this predicts anything: the regime that generated these numbers can shift, and single stocks shift faster than most. Treat this page as a record of what failed under honest testing, not a forecast.
Every figure above is computed from our own backtests — nothing is estimated or invented. Hypothetical results; not investment advice.
The least-bad setups — shown with their failure numbers
Nothing here earned a verdict — these are the best of a losing field, published so you can see exactly how "best" still failed.
Murrey Math Lines
Mechanical rule (exactly as backtested): Murrey Math octave lines — buy the lower octave, exit at the midline. Signals are evaluated at daily-bar close, the position changes on the NEXT bar, 0.08% cost per side, long/flat only — no leverage, no shorting.
Out-of-sample (last ~30% of the window, never used to pick this setup): Sharpe 0.57 · alpha 0.0% · 48 trades over 16.2 yrs.
VWAP Bands
Mechanical rule (exactly as backtested): Rolling VWAP ± standard-deviation bands — buy below the lower band, exit at VWAP. Signals are evaluated at weekly-bar close, the position changes on the NEXT bar, 0.08% cost per side, long/flat only — no leverage, no shorting.
Out-of-sample (last ~30% of the window, never used to pick this setup): Sharpe 0.57 · alpha -2.1% · 15 trades over 16.3 yrs.
Trade Volume Index
Mechanical rule (exactly as backtested): TVI — accumulates volume by tick direction; long while above its average. Signals are evaluated at daily-bar close, the position changes on the NEXT bar, 0.08% cost per side, long/flat only — no leverage, no shorting.
Out-of-sample (last ~30% of the window, never used to pick this setup): Sharpe 0.56 · alpha +1.0% · 59 trades over 16.2 yrs.
Since publication — including if it loses
The forward record is just getting started — the gap between the two is the honest score. Marked to market nightly from real prices, rules frozen at publication, as of 2026-07-02. Currently LONG.
We tested 761 setups (indicator × parameters × timeframe) on Pfizer (PFE). Only setups with ≥30 trades qualify (719 did). Setups are ranked by out-of-sample Sharpe — the last ~30% of history, which standard-parameter rules never saw during selection. Because picking the best of 761 tries mines even the holdout, the VALIDATED verdict additionally requires the top setup’s OOS Sharpe to clear a selection hurdle of 0.91 (√(2 ln N)/√T) AND positive alpha in both windows. Of the eligible setups, 0.1% had positive out-of-sample alpha (median OOS Sharpe 0.18) — the table below is truncated, but this summary covers all of them. Full recipe: methodology · the engine’s contract lives in the repo as STRATEGY_METHODOLOGY.md.
Top 20 of 719 eligible setups
Ranked by out-of-sample Sharpe. Full + out-of-sample columns, costs included. Hypothetical.
| # | Setup | TF | Total ret | Sharpe | Max DD | Win | Trades | α vs B&H | OOS Sharpe | OOS α | OOS trades |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Murrey Math Lines | Daily | >+999% | 0.43 | -43.5% | 74.8% | 151 | -4.0% | 0.57 | 0.0% | 48 |
| 2 | VWAP Bands | Weekly | +884.0% | 0.4 | -31.5% | 72.1% | 43 | -5.8% | 0.57 | -2.1% | 15 |
| 3 | Trade Volume Index | Daily | +119.6% | 0.17 | -72.1% | 38.1% | 97 | -8.6% | 0.56 | +1.0% | 59 |
| 4 | Williams %R | Weekly | +580.3% | 0.29 | -49.2% | 75.7% | 74 | -6.5% | 0.55 | -0.5% | 24 |
| 5 | Bullish Engulfing | Weekly | +323.0% | 0.29 | -67.6% | 54.5% | 101 | -7.4% | 0.52 | -2.8% | 31 |
| 6 | TRIMA 100 Trend | Weekly | >+999% | 0.45 | -75.4% | 34.1% | 41 | -3.3% | 0.49 | -0.5% | 12 |
| 7 | SMA 100 Trend | Weekly | >+999% | 0.47 | -70.3% | 43.1% | 58 | -2.6% | 0.48 | -0.5% | 14 |
| 8 | Perfect Trend Line | Weekly | +204.1% | 0.2 | -78.4% | 49.0% | 347 | -8.0% | 0.46 | -1.3% | 95 |
| 9 | ALMA 200 Trend | Weekly | >+999% | 0.42 | -74.8% | 44.3% | 61 | -3.7% | 0.45 | -1.0% | 16 |
| 10 | Ehlers Reflex | Daily | +358.7% | 0.24 | -85.4% | 48.3% | 458 | -7.2% | 0.45 | -1.4% | 133 |
| 11 | Order-Flow Reversion | Daily | +750.7% | 0.36 | -39.5% | 70.7% | 188 | -6.1% | 0.45 | -2.6% | 63 |
| 12 | Vegas Tunnel | Weekly | >+999% | 0.51 | -46.3% | 36.4% | 33 | -1.6% | 0.44 | -1.1% | 10 |
| 13 | Volatility Stop (ATR) | Weekly | +862.2% | 0.32 | -78.5% | 51.3% | 76 | -5.8% | 0.44 | -1.5% | 21 |
| 14 | Money Flow Index | Daily | >+999% | 0.37 | -47.6% | 79.6% | 49 | -4.8% | 0.44 | -2.0% | 16 |
| 15 | Bollinger Mean-Reversion | Daily | >+999% | 0.43 | -39.5% | 71.0% | 217 | -4.8% | 0.44 | -2.4% | 71 |
| 16 | Fibonacci Bands | Daily | >+999% | 0.43 | -39.5% | 71.0% | 217 | -4.8% | 0.44 | -2.4% | 71 |
| 17 | DeMarker | Weekly | +383.3% | 0.26 | -55.0% | 77.8% | 36 | -7.1% | 0.43 | -2.7% | 13 |
| 18 | Bollinger Mean-Reversion | Weekly | +786.0% | 0.36 | -37.8% | 73.8% | 42 | -6.0% | 0.42 | -3.2% | 15 |
| 19 | Fibonacci Bands | Weekly | +786.0% | 0.36 | -37.8% | 73.8% | 42 | -6.0% | 0.42 | -3.2% | 15 |
| 20 | Order-Flow Reversion | Weekly | +606.7% | 0.34 | -37.8% | 73.7% | 38 | -6.4% | 0.42 | -3.3% | 14 |
Hypothetical backtests with 0.08%/side costs. Not investment advice — see the full disclaimer.
These are historical backtests of mechanical rules. They are educational research, not investment advice, not a recommendation, and not tailored to you. Educational information only — not investment advice. Hypothetical backtested results; past performance does not guarantee future results. Trading involves risk of loss.