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The best indicator for Merck & Co. (MRK)

We backtested 382 indicators across daily, weekly and hourly charts on real Merck & Co. (MRK) history. Here's what actually worked — risk-adjusted over the full backtest, with costs, and checked out-of-sample.

Signaling LONG right now — Supertrend (14,4) (Weekly) has been long for 49 bars. Signal computed on 2026-10-19, 4 days behind the price data on this page (it is rebuilt on a separate schedule).
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Key levels · as of 2026-10-23

Where Merck & Co. (MRK) stands

145.27
last daily close (2026-10-23)
124.61
200-day simple moving average price 16.6% above
146.28
50-day simple moving average price 0.7% below
80.14–155.53
52-week range

Computed from our own daily OHLCV history, not quoted from a third party. Moving averages use closing prices; "52-week" is the last 252 trading sessions.

Trend · Weekly

Supertrend (14,4)

On the weekly chart, this is the strongest risk-adjusted edge we found for Merck & Co. (MRK) over ~65.0 years — trailing buy-and-hold by 1.9% CAGR.

10.9%
CAGR
0.66
Sharpe
-44.0%
Max DD
72.7%
Win rate
18.27
Profit factor
-1.9%
vs Buy&Hold
Chart

Merck & Co. (MRK) on the weekly chart

The timeframe our backtest found best for this asset. The chart is live market data; the results above are hypothetical and historical.

Chart by TradingView. Loading it contacts tradingview.com, which may set its own cookies — see our privacy policy.

NOTHING BEAT BUY-AND-HOLD
Full strategy report — every setup ranked out-of-sample, corrected for data-mining, and forward-tracked in public.
Read the verdict
Confluence · Weekly

Best multi-indicator combo

EMA 20/50 CrossQQE

Going long only when all 2 agree was the strongest confluence setup we found for Merck & Co. (MRK) — trailing buy-and-hold by 2.9% CAGR, out-of-sample. Fewer, higher-conviction trades than any single indicator.

9.6%
CAGR
0.58
Sharpe
52.0%
Win rate
173
Trades
-2.9%
vs Buy&Hold
Best by timeframe

The winner on each chart

Weekly
Supertrend (14,4)
-1.9% · Sharpe 0.66
Daily
EMA 50/200 Cross
-2.0% · Sharpe 0.64
Full results

Every indicator, ranked

Ranked by Sharpe (risk-adjusted return). Hypothetical, fees included.

#IndicatorTFCAGRSharpeMax DDWinTradesvs B&H
1Supertrend (14,4) ✓Weekly10.9%0.66-44.0%72.7%22-1.9%
2EMA 50/200 Cross ✓Daily10.8%0.64-57.4%50.0%38-2.0%
3TRIX (9) ✓Weekly10.8%0.64-46.1%54.4%57-2.0%
4EMA 10/40 Cross ✓Weekly11.1%0.64-59.2%52.6%38-1.8%
5TRIX (21) ✓Weekly11.1%0.64-49.8%65.2%23-1.7%
6CCI (200) ✓Daily10.2%0.63-58.7%28.8%191-2.5%
7Awesome Oscillator ✓Weekly10.6%0.63-52.2%48.3%58-2.2%
8TRIX (15) ✓Weekly10.7%0.63-43.0%63.3%30-2.1%
9SMA 50/200 Cross ✓Daily10.3%0.62-56.4%56.4%39-2.4%
10EMA 20/50 Cross ✓Weekly11.0%0.62-44.5%65.2%23-1.9%
11WMA 20/50 Cross ✓Weekly10.5%0.62-50.1%52.8%36-2.3%
12EMA 9/26 Cross ✓Weekly10.3%0.62-59.2%51.9%54-2.5%
13SMA 10/40 Cross ✓Weekly10.5%0.62-51.7%51.3%39-2.3%
14WMA 10/40 Cross ✓Weekly10.3%0.62-51.0%48.3%58-2.5%

✓ = held up out-of-sample. Hypothetical, costs included. See methodology.

The leverage question

What it would take to beat buy & hold on Merck & Co. (MRK)

3 of 731 tested setups beat buy-and-hold on Merck & Co. (MRK) outright. Another 171 could get there with leverage they would survive — but 257 would be liquidated by their own drawdown before they caught it.

IndicatorBeats B&H unlevered Leverage neededLeverage survived
Intraday Momentum Index1none needed2.47×
T3 10/40 Cross1none needed2.79×
Predictive Ranges1none needed2.91×
EMA 200 Trend—1.39×2.38×
VIDYA 30 Trend—1.4×2.64×
CCI (200)—1.41×2.47×

Out-of-sample, costs included. A setup is only listed if the leverage it needs is less than the leverage its own worst drawdown survives — when it isn't, no amount of leverage gets there. Volatility drag isn't modelled, so these are the optimistic case. Every indicator, ranked this way

What this means

For Merck & Co. (MRK), Supertrend (14,4) on the weekly timeframe gave the best balance of return and risk in our test. It still trailed buy-and-hold on raw return — but remember: this is a hypothetical backtest of a standard rule, not a recommendation. Markets change. See the methodology and disclaimer.

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